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Personal genomics: the importance of sequencing

Those of us who live and breath genomics get very excited about sequencing DNA. Genomes Unzipped will be sure to cover the constant battles between sequencing companies to produce complete and accurate genome sequences for low prices; from our point of view, ‘low prices’ means affordable for consumers, or less than £1000 or so for a full sequence of an individual.

But why do we care about sequencing? You can go to a company like 23andMe and get a genotyping chip done; this won’t give you your full DNA sequence, but it will give you information about half a million sites on your genome, at the much lower cost of around £300. The sites picked for these chips are ones that are most variable in the population, and those that are well-studied. Why do we care about the rest? What more does sequencing give you?
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